Supplements

Apigenin

Evidence: Moderate

Mechanism of Action

Flavonoid (found in chamomile, parsley) that inhibits CD38, the primary NAD+-consuming enzyme. Also a potent aromatase inhibitor and anxiolytic via GABA-A modulation. Supports NAD+ levels, reduces estrogen conversion, and improves sleep quality.

Interactions

  • May enhance effects of benzodiazepines (GABA modulation)
  • CYP1A2 and CYP2C9 inhibitor — caution with substrates

Contraindications

  • Caution in pregnancy (uterotonic potential at high doses)

Key Papers

  • Escande et al. 2013 - CD38 inhibition by flavonoids (Aging Cell)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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