Supplements

Calcium Alpha-Ketoglutarate (Ca-AKG)

Evidence: Moderate (healthspan), Emerging (human longevity)

Mechanism of Action

AKG is a TCA cycle intermediate that declines with age. Supplementation reduces inflammatory cytokines, improves stem cell function, and extends healthspan in mice. Calcium salt form provides sustained release. Also supports collagen synthesis and reduces frailty markers.

Interactions

  • May interact with calcium channel blockers (calcium content)
  • Synergistic with vitamin C for collagen synthesis

Contraindications

  • Hypercalcemia
  • Kidney stones (calcium component)

Key Papers

  • Asadi Shahmirzadi et al. 2020 - AKG extends healthspan in mice (Cell Metabolism)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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