Pharmaceuticals

Canagliflozin

Evidence: Moderate (longevity), Strong (cardiorenal)

Mechanism of Action

SGLT2 inhibitor originally developed for type 2 diabetes. Blocks glucose reabsorption in kidneys, creating a mild glucose deficit that activates AMPK and mimics caloric restriction. Extended lifespan in male mice in the ITP.

Interactions

  • Potentiates hypoglycemia with insulin/sulfonylureas
  • Increases risk of genital mycotic infections
  • May interact with loop diuretics

Contraindications

  • Type 1 diabetes (DKA risk)
  • Severe renal impairment (eGFR <30)
  • History of recurrent UTIs

Key Papers

  • Miller et al. 2020 - Canagliflozin extends lifespan in male mice (Aging Cell)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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