Supplements

DHEA (Dehydroepiandrosterone)

Evidence: moderate_human

Mechanism of Action

DHEA is the most abundant circulating steroid hormone, produced primarily by the adrenal zona reticularis. It serves as a precursor for both androgens (testosterone, DHT via 3beta-HSD and 17beta-HSD) and estrogens (estradiol, estrone via aromatase). DHEA-S (sulfated form) acts as a neurosteroid, positively modulating NMDA receptors and antagonizing GABA-A receptors (cognitive enhancement/alertness). It also modulates immune function (enhances Th1 immunity, IL-2 production), supports bone mineral density via estrogenic metabolites, enhances insulin sensitivity via PPAR-alpha activation, and opposes cortisol's catabolic effects (DHEA:cortisol ratio is a stress/aging biomarker).

Dosing Protocol

Standard: 25-50mg daily (men); 10-25mg daily (women)

Maintenance: 25mg/day (titrate based on blood levels)

Administration: oralsublingualtopical

Timing: Morning (mimics natural circadian peak). With food.

Duration: Ongoing under supervision with regular blood monitoring (DHEA-S, testosterone, estradiol, PSA in men)

Notes

DHEA is a hormone, not just a supplement — treat it accordingly. Blood testing (DHEA-S, free/total testosterone, estradiol, PSA for men) BEFORE and every 3-6 months DURING supplementation is mandatory. DHEA-S levels decline ~80% from age 25 to 75, making it a target for age-related restoration. Women are much more sensitive to androgenic effects and should start at 5-10mg. 7-Keto DHEA is an alternative that does not convert to sex hormones — appropriate for clients wanting metabolic benefits without hormonal changes. In several US states and internationally, DHEA is a controlled substance — check local regulations.

Stacking

  • Pregnenolone
  • Vitamin D3
  • DIM (to manage estrogen conversion)
  • Zinc

Interactions

  • Aromatase inhibitors [MEDIUM] — DHEA provides aromatase substrate — may partially counteract AI therapy
  • Tamoxifen/SERMs [MEDIUM] — DHEA conversion to estrogen may oppose anti-estrogen therapy
  • Insulin/diabetes medications [LOW] — DHEA may improve insulin sensitivity
  • Corticosteroids [LOW] — DHEA opposes cortisol effects — potentially beneficial interaction

Contraindications

  • Hormone-sensitive cancers (prostate, breast, ovarian)
  • PCOS (may worsen androgen excess)
  • Endometriosis
  • Uterine fibroids
  • Children/adolescents

Side Effects

  • Acne (androgenic)
  • Hair loss (androgenic)
  • Hirsutism in women
  • Mood changes (irritability, aggression)
  • Deepening of voice in women (at high doses)
  • Insomnia
  • Oily skin

Key Papers

  • 10.1056/NEJM199410133311501
  • 10.1210/jc.2007-2544
  • 10.1016/j.maturitas.2015.12.010

Source Quality

Pharmaceutical-grade, micronized DHEA. Some products use 7-Keto DHEA (which does not convert to sex hormones — for metabolic benefit without hormonal effects). Brands: Pure Encapsulations DHEA, Life Extension DHEA, Thorne DHEA. Compounding pharmacies for custom dosing.

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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