Supplements

Dihydroberberine (GlucoVantage)

Evidence: Moderate

Mechanism of Action

Active metabolite of berberine with 5x greater absorption. AMPK activator that improves insulin sensitivity, reduces hepatic glucose production, and modulates gut microbiome. More bioavailable form allows lower dosing with fewer GI side effects.

Interactions

  • Same as berberine — CYP2D6/3A4/2C9 inhibitor
  • Potentiates metformin and other antidiabetics
  • May reduce efficacy of cyclosporine

Contraindications

  • Same as berberine — hypoglycemia risk with diabetic medications

Key Papers

  • Turner et al. 2008 - Berberine metabolites and glucose lowering (Metabolism)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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