Adaptogens
Evidence: moderate_human
Holy Basil (Ocimum tenuiflorum) contains eugenol, rosmarinic acid, ursolic acid, and ocimumosides. Eugenol inhibits COX-2 and 5-LOX, providing anti-inflammatory effects. Ursolic acid activates AMPK and inhibits NF-kB. Ocimumosides (A and B) exhibit anti-stress activity by normalizing corticotropin-releasing hormone (CRH) and cortisol levels. Holy Basil also inhibits cortisol synthesis at the adrenal level, modulates GABAergic and serotonergic neurotransmission, has adaptogenic effects via normalization of hypothalamic-pituitary-adrenal axis, and exhibits hypoglycemic action via enhanced insulin secretion and peripheral glucose uptake.
Standard: 500-1000mg daily (standardized extract) or 300mg of high-potency extract
Maintenance: 500mg/day
Administration: oral
Timing: Morning and/or evening with meals. Tulsi tea form is also traditional.
Duration: Cycle 8-12 weeks on, 2-4 weeks off, or ongoing at lower doses
Tulsi is one of the gentlest adaptogens and is well-suited for clients who are sensitive to stronger adaptogens like ashwagandha or rhodiola. The blood sugar-lowering effect is clinically relevant and should be monitored in diabetic clients. The anti-fertility findings in animal studies warrant caution in male clients trying to conceive. Tulsi tea is a pleasant and effective delivery method for daily use. Often used in Ayurvedic protocols for stress, blood sugar, and respiratory support.
OciBest (Natural Remedies) is a standardized extract used in clinical trials. Look for extracts standardized to ursolic acid and/or eugenol content. Whole plant extracts (leaf + stem) preferred. Brands: New Chapter Holy Basil, Organic India Tulsi, Gaia Herbs Holy Basil.
If you want to source it today, here’s a fast Amazon search link (we may earn a small commission at no extra cost).
Search on Amazon →Take the free assessment and get personalized recommendations based on your biology and goals.
Get Your Free Protocolor take the assessment →