Supplements

Palmitoylethanolamide (PEA)

Evidence: Strong

Mechanism of Action

Endocannabinoid-like lipid that activates PPAR-alpha and indirectly enhances endocannabinoid tone. Potent anti-inflammatory and analgesic without acting directly on CB1/CB2. Reduces mast cell activation, neuroinflammation, and chronic pain.

Interactions

  • Generally well-tolerated
  • May enhance effects of other anti-inflammatory agents

Contraindications

  • None established at standard doses

Key Papers

  • Petrosino & Di Marzo 2017 - PEA pharmacology and therapeutic potential (British Journal of Pharmacology)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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