Supplements

Resveratrol

Evidence: moderate_human

Mechanism of Action

Resveratrol activates SIRT1 (the longevity sirtuin) via allosteric binding, promoting deacetylation of PGC-1alpha (mitochondrial biogenesis), FOXO3 (stress resistance), and p53 (DNA repair). It inhibits NF-kB and COX-2, reducing chronic inflammation. Resveratrol also activates AMPK independently of SIRT1 and inhibits phosphodiesterases (PDEs), raising cAMP levels. It improves endothelial function via eNOS upregulation and NO production.

Dosing Protocol

Standard: 250-500mg trans-resveratrol daily

Loading: 1000mg/day for first 2 weeks

Maintenance: 250mg/day

Administration: oralsublingual

Timing: Morning with a fat-containing meal. Often taken alongside NMN for synergistic sirtuin activation.

Duration: ongoing

Notes

Cornerstone of David Sinclair's protocol alongside NMN. Morning fat-soluble dosing is key — Sinclair takes with yogurt. Bioavailability is notoriously poor; micronized or liposomal formulas address this. Pterostilbene is the 'next-gen' alternative with better pharmacokinetics. The estrogen question means careful client screening for hormone-sensitive conditions. High doses (>1g) may paradoxically have pro-oxidant effects.

Stacking

  • NMN
  • Quercetin
  • Pterostilbene
  • Curcumin

Interactions

  • Anticoagulants/antiplatelets [MEDIUM] — Resveratrol has mild antiplatelet activity; additive bleeding risk
  • CYP3A4/CYP1A2 substrates [MEDIUM] — Resveratrol modulates multiple CYP enzymes; may alter drug metabolism
  • Estrogen-sensitive medications [MEDIUM] — Resveratrol has weak estrogenic activity via ERalpha/ERbeta binding

Contraindications

  • Estrogen-sensitive cancers (theoretical ER agonism)
  • Bleeding disorders
  • Pregnancy/lactation

Side Effects

  • GI upset/diarrhea at high doses
  • Headache
  • Joint pain (rare)
  • Insomnia (if taken late)

Key Papers

  • 10.1016/j.cell.2006.11.013
  • 10.1038/nature10600
  • 10.1002/mnfr.201600117

Source Quality

Trans-resveratrol is the bioactive isomer — ensure >98% trans form. Micronized or liposomal for improved bioavailability. Derived from Japanese knotweed (Polygonum cuspidatum) or grape skin. Brands: RevGenetics, Thorne ResveraCel, Nootropics Depot. Pterostilbene (methylated resveratrol) has 4x better bioavailability and may be preferred.

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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