Supplements

Sulforaphane (from Broccoli Sprout Extract)

Evidence: Strong

Mechanism of Action

Isothiocyanate that activates Nrf2 — the master regulator of antioxidant defense. Upregulates glutathione synthesis, phase II detoxification enzymes, and heat shock proteins. Also inhibits HDAC (epigenetic modifier) and NF-kB (anti-inflammatory).

Interactions

  • May reduce effectiveness of CYP1A2 substrates (caffeine)
  • Synergistic with curcumin for NF-kB inhibition

Contraindications

  • Thyroid conditions (goitrogen at very high doses)
  • Cruciferous vegetable allergy

Key Papers

  • Fahey et al. 2017 - Broccoli sprouts and sulforaphane in clinical trials (Molecular Nutrition & Food Research)

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Disclaimer: This information is for educational purposes only and is not medical advice. BioAccelera Labs does not diagnose, treat, or prescribe. Consult a licensed healthcare provider before using any compound.

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